| Specifications | |
|---|---|
| Assay (acidimetric; calculated on dried substance) | 99.5 - 100.5 % |
| Assay (HPLC, calc.on dried substance) | 98.0 - 102.0 % |
| Identity | passes test |
| Appearance of solution (10 %; ethanol 96 %) | passes test |
| Chloride (Cl) | ≤ 0.0100 % |
| Sulphate (SO₄) | ≤ 0.0200 % |
| Heavy metals (as Pb) | ≤ 0.0020 % |
| Related substances / HPLC (EP) (4-Hydroxybenzoic acid) | ≤ 0.1 % |
| Related substances / HPLC (EP) (4-Hydroxyisophthalic acid) | ≤ 0.05 % |
| Related substances / HPLC (EP) (Phenol) | ≤ 0.02 % |
| Related substances / HPLC (EP) (Largest unspecified impurity) | ≤ 0.05 % |
| Related substances / HPLC (EP) (Sum of all impurities) | ≤ 0.2 % |
| Related substances / HPLC (USP) (4-Hydroxybenzoic acid) | ≤ 0.1 % |
| Related substances / HPLC (USP) (4-Hydroxyisophthalic acid) | ≤ 0.05 % |
| Related substances / HPLC (USP) (Phenol) | ≤ 0.02 % |
| Related substances / HPLC (USP) (Largest unspecified impurity) | ≤ 0.05 % |
| Related substances / HPLC (USP) (Sum of all impurities) | ≤ 0.2 % |
| Residual solvents (ICH Q3C) | passes test |
| Sulfated ash | ≤ 0.05 % |
| Loss on drying | ≤ 0.5 % |
| Residues of metal catalysts or metal reagents acc. to EMEA/CHMP/SWP/4446/2000 are not likely to be present. corresponds to Ph Eur, BP, USP |
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Key Spec Table
| CAS # | EC Number | Hill Formula | Chemical Formula | Molar Mass | Grade Value |
|---|---|---|---|---|---|
| 69-72-7 | 200-712-3 | C₇H₆O₃ | HOC₆H₄COOH | 138.12 g/mol | Ph Eur,BP,USP |
| Description | |
|---|---|
| Catalogue Number | 100631 |
| Synonyms | 2-Hydroxybenzoic acid |
| Description | Salicylic acid |
| Product Information | |
|---|---|
| CAS number | 69-72-7 |
| EC number | 200-712-3 |
| Grade | Ph Eur,BP,USP |
| Hill Formula | C₇H₆O₃ |
| Chemical formula | HOC₆H₄COOH |
| Molar Mass | 138.12 g/mol |
| HS Code | 2918 21 00 |
| Structure formula Image | |
| Applications | |
|---|---|
| Application | Salicylic acid suitable for use as excipient EMPROVE® exp Ph Eur,BP,USP. CAS 69-72-7, EC Number 200-712-3, chemical formula HOC₆H₄COOH. Salicylic acid MSDS (material safety data sheet) or SDS, storage and handling info here. Synonyms: 2-Hydroxybenzoic acid |
| Physicochemical Information | |
|---|---|
| Boiling point | 211 °C (1013 hPa) |
| Density | 1.443 g/cm3 (20 °C) |
| Flash point | 157 °C |
| Ignition temperature | 500 °C |
| Melting Point | 157 - 159 °C |
| pH value | 2.4 (H₂O) (saturated solution) |
| Vapor pressure | <1 hPa (100 °C) |
| Bulk density | 400 - 500 kg/m3 |
| Solubility | 2 g/l |
| Toxicological Information | |
|---|---|
| LD 50 oral | LD50 Rat 1250 - 1580 mg/kg |
| LD 50 dermal | LD50 Rat > 2000 mg/kg |
| Safety Information according to GHS | |
|---|---|
| Hazard Pictogram(s) |   |
| Hazard Statement(s) | H302: Harmful if swallowed. H318: Causes serious eye damage. |
| Precautionary Statement(s) | P280: Wear eye protection. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P313: Get medical advice/ attention. |
| RTECS | VO0525000 |
| Storage class | 10 - 13 Other liquids and solids |
| WGK | WGK 1 slightly water endangering |
| Disposal | 3 Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C. |
| Safety Information | |
|---|---|
| Hazard Symbols |  Harmful |
| Categories of danger | harmful, irritant |
| R Phrase | R 22-41 Harmful if swallowed.Risk of serious damage to eyes. |
| S Phrase | S 22-24-26-39 Do not breathe dust.Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear eye/face protection. |
| Storage and Shipping Information | |
|---|---|
| Storage | Store at +15°C to +25°C. |
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